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Scientific Program

Chairpersons: David Lane (US) and Francis Castellino (US)
The role of the protein C system in pathologic
processes	SA-TU-007
Francis Castellino (US)	11:00 - 11:30 AM
Modifier genes for disorders of thrombosis and
hemostasis	SA-TU-008
David Ginsburg (US)	11:30 - 12:00 PM
The many faces of tissue factor	SA-TU-009
Nigel Mackman (US)	12:00 - 12:30 PM

Chairpersons: Yujiro Asada (JP) and Gwendalyn Randolph (US)
Dysfunctional HDL - Lipoprotein at the crossroads of inflammation, oxidant stress and reverse cholesterol transport	SA-TU-0010
Stanley Hazen (US)	11:00 - 11:30 AM
Dendritic cell and macrophage emigration from atheromatous plaque	SA-TU-0011
Gwendalyn Randolph (US)	11:30 - 12:00 PM
Progenitor cell trafficking to the vessel wall	SA-TU-0012
Christian Weber (DE)	12:00 - 12:30 PM

Chairpersons: Marc Jacquemin (BE) and Birgit Reipert (AT)
The role of regulatory T cells in tolerance to
coagulation factors	SA-TU-0013
Roland Herzog (US)	11:00 - 11:30 AM
Opportunities and limitations of mouse models
humanized for HLA class II antigens	SA-TU-0014
Birgit Reipert (AT)	11:30 - 12:00 PM
Clinical prediction models for inhibitor development	SA-TU-0015
Marijke van den Berg (NL)	12:00 - 12:30 PM

Abstract Symposia consist of an invited speaker and four highly rated abstracts presented on a related general theme

Chairperson: Douglas Cines (US)
Controversies in ITP	AS-TU-001
Douglas Cines (US)	1:15 - 1:45 PM

AS-TU-002
1:45 - 2:00 PM
ORAL ELTROMBOPAG REDUCES THE NEED FOR CONCOMITANT MEDICATIONS IN PATIENTS WITH CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA (ITP)
P. Fogarty, J. B. Bussel* (US), G. Cheng, M. N. Saleh, B. Meddeb, C. Bailey, A. Brainsky

AS-TU-003
2:00 - 2:15 PM
SAFETY OF ALTERNATIVE TREATMENTS FOR ITP: META-ANALYSIS
N. Cooper* (UK), M. D. Tarantino

AS-TU-004
2:15 - 2:30 PM
PLATELET VOLUME, PLATELET DIAMETER AND THROMBOPOIETIN LEVEL FOR DIFFERENTIATING INHERITED THROMBOCYTOPENIAS FROM IDIOPATHIC THROMBOCYTOPENIC PURPURA
P. Noris* (IT), A. Pecci, L. Arcaini, V. Bozzi, A. di Cesare Merlone, F. Passamonti, F. Melazzini, M. Zecca, C. Balduini

AS-TU-005
2:30 - 2:45 PM
STORE-OPERATED CALCIUM ENTRY IS ESSENTIAL FOR FC GAMMA RECEPTOR ACTIVATION AND AUTOIMMUNE THROMBOCYTOPENIA
D. Stegner* (DE), A. Braun, S. N. Syed, S. Konrad, A. Berna-Erro, D. Varga-Szabo, J. E. Gessner, B. Nieswandt

Chairperson: Susan Kahn (US)
The post-thrombotic syndrome: Epidemiology
and management	AS-TU-006
Susan Kahn (US)	1:15 - 1:45 PM

AS-TU-007
1:45 - 2:00 PM
RISK FACTORS FOR VENOUS INSUFFICIENCY THAT RESEMBLES POST-THROMBOTIC SYNDROME
M. Cushman* (US), P. W. Callas, M. H. Criqui, J. O. Denenberg, E. G. Bovill

AS-TU-008
2:00 - 2:15 PM
MILD SIGNS OF POST-THROMBOTIC SYNDROME ARE NOT RARE IN CHILDHOOD CANCER SURVIVORS TREATED WITH HICKMAN CATHETERS
M. Menahem, M. Weintraub, S. Revel-Vilk* (IL)

AS-TU-009
2:15 - 2:30 PM
PROGNOSTIC FACTORS OF PULMONARY EMBOLISM. A PROSPECTIVE MULTIleft COHORT STUDY. THE PREP STUDY
O. Sanchez, L. Trinquart, V. Caille, F. Couturaud, G. Pacouret, N. Meneveau, F. Verschuren, P. Roy, F. Parent, A. Perrier, C. Lorut, B. Tardy, M. Benoit, G. Chatellier, G. Meyer* (FR)

AS-TU-010
2:30 - 2:45 PM
RIGHT VENTRICULAR EJECTION FRACTION MEASURED BY ELECTROCARDIOGRAPHYSYNCHRONIZED MULTI-DETECTOR ROW CT ANGIOGRAPHY PREDICTS CLINICAL OUTCOME IN PATIENTS WITH ACUTE PULMONARY EMBOLISM - THE PROBE STUDY
F. A. Klok* (NL), N. van der Bijl, A. de Roos, L. J. M. Kroft, M. V. Huisman

Chairperson: Amit Nathwani (UK)
Gene therapy for haemophilia B	AS-TU-011
Amit Nathwani (UK)	1:15 - 1:45 PM

AS-TU-012
1:45 - 2:00 PM
ENCAPSULATED FETAL MOUSE MYOBLASTS SECRETING FVIII AS A GENE THERAPY STRATEGY FOR HEMOPHILIA
A R. Sengupta* (CA), H. Matsui, J. Wen, D. Lillicrap, G. Hortelano

AS-TU-013
2:00 - 2:15 PM
INDUCTION OF IMMUNO TOLERANCE TO CANINE FVIII (CFVIII) USING LIVER DIRECTED, AAV MEDIATED EXPRESSION OF CFVIII IN HEMOPHILIA A DOGS WITH INHIBITOR ANTIBODIES J. D. Finn* (US), D. E. Sabatino, M. C. Ozelo, S. Zhou, D. Lillicrap, H. H. Kazazian, T. C. Nichols, V. R. Arruda

AS-TU-014
2:15 - 2:30 PM
IMPLANTING GENETICALLY ENGINEERED ENDOTHELIAL PROGENITOR CELLS IN THE OMENTUM OF DOGS RESULTS IN PERSISTENT FVIII EXPRESSION AND CELL VIABILITY
M. C. Ozelo* (CA), H. Matsui, M. McMurray, C. Hegadorn, L. Harpell, S. Powell, C. Hough, D. Lillicrap

AS-TU-015
2:30 - 2:45 PM
SUBSTANTIAL IMPACT OF THE GENETIC MUTATION AND THE GENE TRANSFER PROTOCOL ON IMMUNE RESPONSES TO FACTOR IX IN AAV-BASED THERAPY FOR HEMOPHILIA B
B. E. Hoffman* (US), O. Cao, B. Moghimi, S. Nayak, M. Cooper, S. Zhou, H. Ertl, K. A. High, R. W. Herzog

Chairperson: Pete Lollar (US)
The immune response to factor VIII	AS-TU-016
Pete Lollar (US)	1:15 - 1:45 PM

AS-TU-017
1:45 - 2:00 PM
FACTOR V IS A COFACTOR FOR ACTIVATION OF FACTOR XI BY THROMBIN
C. Maas* (NL), J. C. M. Meijers, C. Weeterings, P. G. de Groot, R. T. Urbanus

AS-TU-018
2:00 - 2:15 PM
NOVEL ROLE FOR CONNEXIN37 IN FVIII SECRETION AND COAGULATION
L. Burnier* (CH), A. Pfenniger, R. Sugamele, I. Roth, M. Delmar, P. Fontana, B. R. Kwak, A. Angelillo-Scherrer

AS-TU-019
2:15 - 2:30 PM
ACTIVATED PROTEIN C COFACTOR FUNCTION OF PROTEIN S: A CRITICAL ROLE FOR THE EGF1LIKE DOMAIN
H. M. Andersson* (UK), M. J. Arantes, J. T. B. Crawley, B. M. Luken, D. A. Lane, S. M. Rezende

AS-TU-020
2:30 - 2:45 PM
PLG-RKT, A NOVEL, STRUCTURALLY UNIQUE, AND DEVELOPMENTALLY REGULATED TRANSMEMBRANE RECEPTOR FOR PLASMINOGEN
L. A. Miles* (US), N. M. Andronicos, E. I. Chen, N. Baik, H. Bai, M. P. Kamps, J. R. Yates Iii, R. J. Parmer

Chairperson: Bernd Engelmann (DE)
Activation of tissue factor-triggered coagulation
by proteindisulfide isomerase	AS-TU-021
Bernd Engelmann (DE)	1:15 - 1:45 PM

AS-TU-022
1:45 - 2:00 PM
PLATELET INDEPENDENT ENDOTHELIUM-DERIVED PROTEIN DISULFIDE ISOMERASE IS REQUIRED FOR FIBRIN GENERATION DURING THROMBUS FORMATION IN VIVO
R. Jasuja* (US), G. Merrill-Skoloff, B. Furie, B. C. Furie

AS-TU-023
2:00 - 2:15 PM
ENDOTHELIAL CELL REGULATION OF BLOOD COAGULATION: A MODEL FOR VENOUS STASIS
J. E. Campbell* (US), M. F. Whelihan, K. E. Brummel-Zeidens, T. Orfeo, J. Krudysz-Amblo, S. Butenas, K. G. Mann

AS-TU-024
2:15 - 2:30 PM
ANTITHROMBOTIC AND ANTIFIBRINOLYTIC EFFECTS OF PLATELET PROTEASE NEXIN-1
Y. Boulaftali* (FR), F. Adam, L. Venisse, S. Loyau, V. Ollivier, M. Alessi, M. Bryckaert, R. Favier, V. Arocas, M. Jandrot-Perrus, M. Bouton

AS-TU-025
2:30 - 2:45 PM
CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF VITAMIN K EPOXIDE REDUCTASE
W. Li* (US), S. Schulman, R. Dutton, D. Boyd, J. Beckwith, T. Rapoport

Chairperson: David Phillips (US)
New directions in antithrombotic drug discovery	AS-TU-026
David Phillips (US)	1:15 - 1:45 PM

AS-TU-027
1:45 - 2:00 PM
IN VIVO ANTI-THROMBOTIC EFFECT OF AN INHIBITOR OF PLATELET GLYCOPROTEIN IB-IX-14-3-3 INTERCTION AND ITS THERAPEUTIC ACTION IN ENDOTOXEMIC MOUSE MODELS H. Yin* (US), J. Lu, Z. Wang, X. Du

AS-TU-028
2:00 - 2:15 PM
GENETIC DELETION OF SEMAPHORIN 4D (SEMA4D) AMELIORATES PLATELET HYPERSENSITIVITY IN DYSLIPIDEMIA AND CONFERS PROTECTION AGAINST THE DEVELOPMENT OF ATHEROSCLEROSIS
T. J. Stalker* (US), L. Zhu, K. P. Fong, H. Jiang, A. Tran, I. Crichton, E. K. Lee, K. B. Neeves, S. F. Maloney, A. Kumanongoh, E. Pure, S. L. Diamond, L. F. Brass

AS-TU-029
2:15 - 2:30 PM
THROMBUS STABILIZATION BY P2Y12 RECEPTORS CONTRIBUTES TO ATHEROTHROMBOSIS AND IS RESTRICTED TO HIGH SHEAR FLOW CONDITIONS
R. Nergiz-Unal* (NL), J. M. E. M. Cosemans, P. J. E. van der Meijden, M. A. H. Feijge, M. G. A. Oude Egbrink, J. W. M. Heemskerk, M. J. E. Kuijpers

AS-TU-030
2:30 - 2:45 PM
MATERNAL IMMUNE RESPONSE TO FETAL PLATELET GPIBALPHA CAUSES MORE FREQUENT MISCARRIAGE THAT CAN BE PREVENTED BY BOTH IVIG AND ANTIBODIES AGAINST THE NEONATAL FC RECEPTOR
C. Li* (CA), S. Piran, P. Chen, G. Zhu, S. Lang, J. Ware, Z. Ruggeri, J. Freedman, H. Ni

Chairperson: Thorsten Steiner (DE)
Intracranial hemorrhage: Threats and chances	AS-TU-031
Thorsten Steiner (DE)	1:15 - 1:45 PM

 

AS-TU-032
1:45 - 2:00 PM
INTRACRANIAL HAEMORRHAGE IN HAEMOPHILIA A AND B: AN ITALIAN RETROSPECTIVE SURVEY
E. Zanon* (IT), L. Spiezia, E. Santagostino, A. Coppola, A. Tagliaferri, G. Rossetti, A. Iorio, R. Santoro, A. Dragani, A. Giuffrida, R. Musso, G. Mancuso, G. Castaman, G. Gamba, G. Mazzucconi, M. Lapecorella

AS-TU-033
2:00 - 2:15 PM
CENTRAL NERVOUS SYSTEM (CNS) BLEEDING IN PATIENTS WITH RARE BLEEDING DISORDERS (RBDS)
S. M. Siboni, E. Zanon, G. Sottilotta, D. Mikovic, A. Iorio, G. Castaman, M. Mazzucconi, P. M. Mannucci, F. Peyvandi* (IT)

AS-TU-034
2:15 - 2:30 PM
WHEN SHOULD WARFARIN BE RESTARTED AFTER INTRACRANIAL HEMORRHAGE?
A. Majeed, Y. Kim, M. Holmström, S. Schulman* (CA)

AS-TU-035
2:30 - 2:45 PM
SERIAL CHANGES IN VON WILLEBRAND FACTOR AND ADAMTS13 IN PATIENTS WITH AND WITHOUT DELAYED CEREBRAL ISCHEMIA AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
K. Bakhtiari* (NL), M. D. I. Vergouwen, N. van Geloven, M. Vermeulen, Y. B. W. E. Roos, J. C. M. Meijers

 

AS-TU-042
1:45 - 2:00 PM

GLYCOGEN SYNTHASE KINASE-3 NEGATIVELY REGULATES TISSUE FACTOR GENE EXPRESSION IN MONOCYTES INTERACTING WITH ACTIVATED PLATELETS. A NOVEL MECHANISM LINKING THROMBOTIC RISK AND METABOLIC DISORDERS
A. di Santo, C. Amore, S. Manarini, V. Evangelista* (IT)

AS-TU-043
2:00 - 2:15 PM
VASCULAR AND INNATE IMMUNE CELL SIGNALING CONTRIBUTE TO LETHALITY PROTECTION BY ACTIVATED PROTEIN C IN MURINE SEPSIS MODELS
C. Furlan-Freguia* (US), F. Niessen, J. A. Fernández, L. O. Mosnier, F. J. Castellino, H. Rosen, H. Weiler, J. H. Griffin, W. Ruf

AS-TU-044
2:15 - 2:30 PM
CONTRIBUTION OF EGFR TO LPS-INDUCED INFLAMMATION AND COAGULATION
R. Pawlinski* (US), N. Mackman

AS-TU-045
2:30 - 2:45 PM
REDUCTION OF PROTHROMBIN IN MICE ATTENUATES THE DEVELOPMENT OF PARALYSIS ASSOCIATED WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
E. S. Mullins* (US), K. W. Kombrinck, M. J. Flick, J. S. Palumbo, K. E. Talmage, M. A. Shaw, K. Akassaglou, J. L. Degen

Chairperson: Alessandro Vannucchi (IT)
Mechanisms of thrombosis in myeloproliferative	AS-TU-046
neoplasms
Alessandro Vannucchi (IT)	1:15 - 1:45 PM

AS-TU-047
1:45 - 2:00 PM
EVALUATION OF HAEMOSTASIS AND THROMBOSIS RESPONSES IN A THROMBOCYTOSIS MOUSE MODEL
C. Strassel* (FR), P. Mangin, M. Freund, J. Cazenave, R. Skoda, G. Chrisitian, F. Lanza

AS-TU-048
2:00 - 2:15 PM
CHARACTERIZATION OF THE THROMBIN GENERATION (TG) POTENTIAL OF PLATELETS FROM ESSENTIAL THROMBOCYTHEMIA (ET) AND POLYCYTHEMIA VERA (PV) PATIENTS
M. Panova-Noeva* (IT), M. Marchetti, H. Spronk, G. Finazzi, A. Rambaldi, T. Barbui, H. ten Cate, A. Falanga

AS-TU-049
2:15 - 2:30 PM
CIRCULATING ENDOTHELIAL PROGENITOR CELLS AND RESIDUAL IN VIVO THROMBOXANE BIOSYNTHESIS IN LOW-DOSE ASPIRIN-TREATED POLYCYTHEMIA VERA PATIENTS
F. Santilli* (IT), M. Romano, A. Recchiuti, A. Dragani, A. Falco, G. Lessiani, F. Fioritoni, S. Lattanzio, D. Mattoscio, R. de Cristofaro, B. Rocca, G. Davì

AS-TU-050 2:30 - 2:45 PM
MONOCYTE (MNC) HEMOSTATIC PROFILE IN ESSENTIAL THROMBOCYTHEMIA (ET) OR POLYCYTHEMIA VERA (PV) PATIENTS IS INFLUENCED BY JAK2V617F MUTATIONAL LOAD
A. Vignoli* (IT), M. Marchetti, L. Russo, M. Panova-Noeva, S. Salmoiraghi, T. Barbui, A. Rambaldi, H. ten Cate, A. Falanga

Chairperson: Neil Goldenberg (US)
Neonatal and childhood arterial ischemic stroke	AS-TU-051
Neil Goldenberg (US)	1:15 - 1:45 PM

AS-TU-052
1:45 - 2:00 PM
ANTIPHOSPHOLIPID ANTIBODIES OF INFANTS WITH CEREBRAL EVENTS - A UNIQUE ENTITY OR VARIANT OF ANTIPHOSPHOLIPID SYNDROME?
Y. Berkun, M. Simchen, T. Strauss, S. Menashku, S. Padeh, G. Kenet* (IL)

AS-TU-053
2:00 - 2:15 PM
GENETIC VARIATION IN THE C-REACTIVE PROTEIN GENE AND THE IL4-IL13 GENE CLUSTER IS ASSOCIATED WITH VASCULAR STROKE IN CHILDREN
U. Nowak-Gottl, A. Huge, S. Thedieck, M. Stoll* (DE)

AS-TU-054
2:15 - 2:30 PM
IN PEDIATRIC PATIENTS, AGE HAS MORE IMPACT ON ORAL ANTICOAGULANT DOSE THAN VKORC1 OR CYP2CP GENOTYPES
U. Nowak Göttl, K. Dietrich, N. Eldin, Y. Yasui, C. Geissen, L. G. Mitchell* (CA)

AS-TU-055 2:30 - 2:45 PM
A SIGNIFICANT INCREASE IN VENOUS THROMBOEMBOLISM IN HOSPITALIZED CHILDREN IN THE UNITED STATES FROM 2001 TO 2007
L. J. Raffini* (US), Y. Huang, C. Witmer, C. Feudtner

Chairperson: Philip Marsden (CA)
Regulation of vascular endothilial gene expression: The role of epigenetics	AS-TU-056
Philip Marsden (CA)	1:15 - 1:45 PM

AS-TU-057
1:45 - 2:00 PM
MIRNA-DEPENDENT REGULATION OF SMOOTH MUSCLE CELL FUNCTION
W. Bielenberg* (DE), A. Prock, H. Tillmanns, D. G. Sedding

AS-TU-058
2:00 - 2:15 PM
THE TRANSCRIPTIONAL MACHINERY RESPONSIBLE FOR THE TISSUE-SPECIFIC EXPRESSION OF THE MURINE MVWF1 GENE IS CONSERVED IN ZEBRAFISH
Y. Kalish* (US), J. Johnsen, D. Ginsburg

AS-TU-059
2:15 - 2:30 PM
BIO-MECHANICAL REGULATION OF MICRORNA EXPRESSION AND ENDOTHELIAL CELL PHENOTYPE IN VITRO
A. Murphy* (IE), M. Britto, P. Fitzpatrick, N. Barron, D. O'Gorman, N. Moyna, P. Cummins, R. P. Murphy

AS-TU-060
2:30 - 2:45 PM
GAS6 REGULATES DIFFERENT INFLAMMATORY RESPONSES TO TNF AND LPS IN ENDOTHELIAL CELLS
L. Bellido-Martin* (ES), P. Garcia de Frutos

Introducer: Edwin Bovill (US)

PL-TU-001
3:20 - 3:30 PM
GENOME-WIDE SCAN IN AFFECTED SIBLING PAIRS (GIFT STUDY) IDENTIFIES A NOVEL SUSCEPTIBILITY REGION FOR VENOUS THROMBOEMBOLISM
M. C. H. de Visser* (NL), R. van Minkelen, V. van Marion, M. den Heijer, J. C. J. Eikenboom, H. L. Vos, P. E. Slagboom, J. J. Houwing-Duistermaat, R. M. Bertina

Introducer: Kenneth Kaushansky (US)

PL-TU-002
3:35 - 3:45 PM
EXAMINATION OF THE FINAL STAGES OF PLATELET PRODUCTION
J. N. Thon* (US), A. Montalvo, S. R. Patel, J. L. Richardson, J. H. Hartwig, J. E. Italiano Introducer: George Broze (US)

PL-TU-003
3:50 - 4:00 PM
FEEDBACK ACTIVATION OF FACTOR XI BY THROMBIN IS ESSENTIAL FOR HAEMOSTASIS IN VIVO
H. M. H. Spronk* (NL), S. Wilhelm, J. W. M. Heemskerk, H. ten Cate, M. L. Knetsch, D. Gailani, R. Pawlinski, N. Mackman, T. Renné

Introducer: Pete Lollar (US)

PL-TU-004
4:20 - 4:30 PM
EVIDENCE OF THE FIRST X-LINKED THROMBOPHILIA DUE TO A NOVEL MUTATION IN CLOTTING FACTOR IX GENE RESULTING IN HYPERFUNCTIONAL FIX: FACTOR IX ARGININE 338 LEUCINE (FACTOR IX PADUA)
P. Simioni* (IT), D. Tormene, G. Tognin, S. Gavasso, C. Bulato, N. Iacobellis, J. Finn, L. Spiezia, C. Radu, V. Arruda

Introducer: Mark Ginsberg (US)

PL-TU-005
4:35 - 4:45 PM
KINDLIN3 IN INTEGRIN ACTIVATION
T. V. Byzova* (US), N. Malinin, J. Choi, A. Ciocea, L. Zhang, E. Podrez, M. Tosi, D. Lennon, A. Caplan, E. Plow, S. Shurin

Introducer: Hartmut Weiler (US)

PL-TU-006
4:50 - 5:00 PM
THROMBOMODULIN MUTATIONS PREDISPOSE TO ATYPICAL HEMOLYTIC-UREMIC SYNDROME VIA IMPAIRED COMPLEMENT REGULATION
M. Delvaeye* (BE), M. Noris, A. de Vriese, C. T. Esmon, N. L. Esmon, D. Lambrechts, G. Remuzzi, E. M. Conway